Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell–derived cytokines
ML Giustizieri, F Mascia, A Frezzolini, O De Pità… - Journal of Allergy and …, 2001 - Elsevier
Background: Atopic dermatitis (AD) and psoriasis are genetically determined inflammatory
skin disorders. Keratinocytes actively participate in cutaneous inflammatory responses by
elaborating various chemokines. Objective: We investigated the capacity of IL-4, IFN-γ, and
TNF-α to modulate the expression of CCL and CXCL chemokines in cultured keratinocytes
from patients and healthy individuals, as well as chemokine expression in situ. Methods:
Keratinocyte cultures were established from normal-looking skin of adult patients with AD or …
skin disorders. Keratinocytes actively participate in cutaneous inflammatory responses by
elaborating various chemokines. Objective: We investigated the capacity of IL-4, IFN-γ, and
TNF-α to modulate the expression of CCL and CXCL chemokines in cultured keratinocytes
from patients and healthy individuals, as well as chemokine expression in situ. Methods:
Keratinocyte cultures were established from normal-looking skin of adult patients with AD or …
