T cell anergy
RH Schwartz - Annual review of immunology, 2003 - annualreviews.org
T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally
inactivated following an antigen encounter, but remains alive for an extended period of time
in a hyporesponsive state. Models of T cell anergy affecting both CD4+ and CD8+ cells fall
into two broad categories. One, clonal anergy, is principally a growth arrest state, whereas
the other, adaptive tolerance or in vivo anergy, represents a more generalized inhibition of
proliferation and effector functions. The former arises from incomplete T cell activation, is …
inactivated following an antigen encounter, but remains alive for an extended period of time
in a hyporesponsive state. Models of T cell anergy affecting both CD4+ and CD8+ cells fall
into two broad categories. One, clonal anergy, is principally a growth arrest state, whereas
the other, adaptive tolerance or in vivo anergy, represents a more generalized inhibition of
proliferation and effector functions. The former arises from incomplete T cell activation, is …