Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease
S Apostolakis, S Baritaki, GE Kochiadakis… - Thrombosis research, 2007 - Elsevier
INTRODUCTION: Atherosclerosis, the underlying disorder of coronary artery disease (CAD),
is an inflammatory process involving multiple molecular pathways. Chemokine-mediated
mechanisms are potent regulators of atherosclerosis. Genetic variations that alter such
signaling pathways could affect susceptibility to CAD. We investigated the effect of 5
common variations of chemokine and chemokine receptor genes (SDF1-3′ A, CCR5-
delta32, CCR2-64I, CX3CR1-V249I and CX3CR1-T280M) on predisposition to CAD …
is an inflammatory process involving multiple molecular pathways. Chemokine-mediated
mechanisms are potent regulators of atherosclerosis. Genetic variations that alter such
signaling pathways could affect susceptibility to CAD. We investigated the effect of 5
common variations of chemokine and chemokine receptor genes (SDF1-3′ A, CCR5-
delta32, CCR2-64I, CX3CR1-V249I and CX3CR1-T280M) on predisposition to CAD …
