[HTML][HTML] Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer-binding protein family members
MJ Ruddy, GC Wong, XK Liu, H Yamamoto… - Journal of Biological …, 2004 - ASBMB
Interleukin (IL)-17 is a recently described cytokine involved in the amplification of
inflammatory responses and pathologies. A hallmark feature of IL-17 is its ability to induce
expression of other cytokines and chemokines. In addition, IL-17 potently synergizes with
tumor necrosis factor-α (TNFα) to up-regulate expression of many target genes, particularly
IL-6. Despite the many observations of IL-17 signaling synergy observed to date, little is
known about the molecular mechanisms that underlie this phenomenon. In the osteoblastic …
inflammatory responses and pathologies. A hallmark feature of IL-17 is its ability to induce
expression of other cytokines and chemokines. In addition, IL-17 potently synergizes with
tumor necrosis factor-α (TNFα) to up-regulate expression of many target genes, particularly
IL-6. Despite the many observations of IL-17 signaling synergy observed to date, little is
known about the molecular mechanisms that underlie this phenomenon. In the osteoblastic …