The rational designed antagonist derived from the complex structure of interleukin-6 and its receptor affectively blocking interleukin-6 might be a promising treatment …
J Feng, Z Yang, Y Li, M Hu, M Yu, W Qin, J Sun, B Shen - Biochimie, 2006 - Elsevier
Human interleukin-6 is involved in the maintenance and progression of several diseases
such as multiple myeloma (MM), rheumatoid arthritis, or osteoporosis. Our previous work
demonstrated that an interleukin-6 antagonist peptide (named PT) possessed potential
bioactivity to antagonize the function of hIL-6 and could efficiently induce the growth arrest
and apoptosis of XG-7 and M1 cells in a dose-dependent manner. In this study, the
theoretical interaction of the peptide PT with its receptor was analyzed further more with …
such as multiple myeloma (MM), rheumatoid arthritis, or osteoporosis. Our previous work
demonstrated that an interleukin-6 antagonist peptide (named PT) possessed potential
bioactivity to antagonize the function of hIL-6 and could efficiently induce the growth arrest
and apoptosis of XG-7 and M1 cells in a dose-dependent manner. In this study, the
theoretical interaction of the peptide PT with its receptor was analyzed further more with …