Association of interleukin‐1 gene polymorphisms with Alzheimer's disease
JAR Nicoll, RE Mrak, DI Graham… - Annals of Neurology …, 2000 - Wiley Online Library
JAR Nicoll, RE Mrak, DI Graham, J Stewart, G Wilcock, S MacGowan, MM Esiri, LS Murray…
Annals of Neurology: Official Journal of the American Neurological …, 2000•Wiley Online LibraryAbstract Interleukin‐1 (IL‐1) is markedly overexpressed in Alzheimer's disease. We found
the IL‐1A 2, 2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease
patients and 6.6% of 167 controls from four centers in the United Kingdom and United States
(odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity
for both allele 2 of IL‐1A and allele 2 of IL‐1B conferred even greater risk (odds ratio, 10.8).
IL‐1 genotypes may confer risk for Alzheimer's disease through IL‐1 overexpression and IL …
the IL‐1A 2, 2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease
patients and 6.6% of 167 controls from four centers in the United Kingdom and United States
(odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity
for both allele 2 of IL‐1A and allele 2 of IL‐1B conferred even greater risk (odds ratio, 10.8).
IL‐1 genotypes may confer risk for Alzheimer's disease through IL‐1 overexpression and IL …
Abstract
Interleukin‐1 (IL‐1) is markedly overexpressed in Alzheimer's disease. We found the IL‐1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL‐1A and allele 2 of IL‐1B conferred even greater risk (odds ratio, 10.8). IL‐1 genotypes may confer risk for Alzheimer's disease through IL‐1 overexpression and IL‐1–driven neurodegenerative cascades. Ann Neurol 2000;47:365–368
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