Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease
J Rogers, LF Lue - Neurochemistry international, 2001 - Elsevier
Microglia are widely held to play important pathophysiologic roles in Alzheimer's disease
(AD). On exposure to amyloid β peptide (Aβ) they exhibit chemotactic, phagocytic,
phenotypic and secretory responses consistent with scavenger cell activity in a localized
inflammatory setting. Because AD microglial chemotaxis, phagocytosis, and secretory
activity have common, tightly linked soluble intermediaries (eg, cytokines, chemokines), cell
surface intermediaries (eg, receptors, opsonins), and stimuli (eg, highly inert Aβ deposits …
(AD). On exposure to amyloid β peptide (Aβ) they exhibit chemotactic, phagocytic,
phenotypic and secretory responses consistent with scavenger cell activity in a localized
inflammatory setting. Because AD microglial chemotaxis, phagocytosis, and secretory
activity have common, tightly linked soluble intermediaries (eg, cytokines, chemokines), cell
surface intermediaries (eg, receptors, opsonins), and stimuli (eg, highly inert Aβ deposits …