BAFF AND APRIL: a tutorial on B cell survival
F Mackay, P Schneider, P Rennert… - Annual review of …, 2003 - annualreviews.org
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and
mature B cells. BAFF overexpression leads to an expanded B cell compartment and
autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of
autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears
to play a different biological role. The BAFF system provides not only potential insight into
the development of autoreactive B cells but a relatively simple paradigm to begin …
mature B cells. BAFF overexpression leads to an expanded B cell compartment and
autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of
autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears
to play a different biological role. The BAFF system provides not only potential insight into
the development of autoreactive B cells but a relatively simple paradigm to begin …