[HTML][HTML] A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini
C Schäfer, SE Ross, MJ Bragado… - Journal of Biological …, 1998 - ASBMB
Cholecystokinin (CCK) and other pancreatic secretagogues have recently been shown to
activate signaling kinase cascades in pancreatic acinar cells, leading to the activation of
extracellular signal-regulated kinases and Jun N-terminal kinases. We now show the
presence of a third kinase cascade activating p38 mitogen-activated protein (MAP) kinase in
isolated rat pancreatic acini. CCK and osmotic stress induced by sorbitol activated p38 MAP
kinase within minutes; their effects were dose-dependent, with maximal activation of 2.8-and …
activate signaling kinase cascades in pancreatic acinar cells, leading to the activation of
extracellular signal-regulated kinases and Jun N-terminal kinases. We now show the
presence of a third kinase cascade activating p38 mitogen-activated protein (MAP) kinase in
isolated rat pancreatic acini. CCK and osmotic stress induced by sorbitol activated p38 MAP
kinase within minutes; their effects were dose-dependent, with maximal activation of 2.8-and …