Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci …
K Cao, J Hollenbach, X Shi, W Shi, M Chopek… - Human immunology, 2001 - Elsevier
The HLA system is the most polymorphic of all human genetic systems. The frequency of
HLA class I alleles and their linkage disequilibrium patterns differ significantly among human
populations as shown in studies using serologic methods. Many DNA-defined alleles with
identical serotypes may have variable frequencies in different populations. We typed HLA-A,
B, and C loci at the allele level by PCR-based methods in 1,296 unrelated subjects from five
major outbred groups living in the USA (African, AFAM; Caucasians, CAU; Asian, ORI; …
HLA class I alleles and their linkage disequilibrium patterns differ significantly among human
populations as shown in studies using serologic methods. Many DNA-defined alleles with
identical serotypes may have variable frequencies in different populations. We typed HLA-A,
B, and C loci at the allele level by PCR-based methods in 1,296 unrelated subjects from five
major outbred groups living in the USA (African, AFAM; Caucasians, CAU; Asian, ORI; …