Poloxamer 188 failed to prevent exercise-induced membrane breakdown in mdx skeletal muscle fibers
JG Quinlan, BL Wong, RT Niemeier… - Neuromuscular …, 2006 - Elsevier
We sought to determine the effectiveness of poloxamer 188 (P188) in protecting dystrophin-
deficient, mdx skeletal muscle fiber membrane against exercise-induced breaches. mdx
mice were treated with either P188 or placebo via intraperitoneal injections and run on a
treadmill for 60–90min. Membrane breakdown was quantified in cross-sections of rectus
femoris muscle pretreated with Evans blue dye (in vivo). The mean% dye-penetrated muscle
in the P188 and placebo groups was not significantly different in each of three trials. These …
deficient, mdx skeletal muscle fiber membrane against exercise-induced breaches. mdx
mice were treated with either P188 or placebo via intraperitoneal injections and run on a
treadmill for 60–90min. Membrane breakdown was quantified in cross-sections of rectus
femoris muscle pretreated with Evans blue dye (in vivo). The mean% dye-penetrated muscle
in the P188 and placebo groups was not significantly different in each of three trials. These …