Low sensitivity of a whole-blood interferon-γ release assay for detection of active tuberculosis
PK Dewan, J Grinsdale… - Clinical infectious …, 2007 - academic.oup.com
PK Dewan, J Grinsdale, LM Kawamura
Clinical infectious diseases, 2007•academic.oup.comThe sensitivity of an interferon-γ assay (Quantiferon-TB Gold; Cellestis) was evaluated for
the detection of tuberculosis among 242 persons with suspected tuberculosis in San
Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1
indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had
positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that
the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.
the detection of tuberculosis among 242 persons with suspected tuberculosis in San
Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1
indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had
positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that
the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.
Abstract
The sensitivity of an interferon-γ assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.
Oxford University Press