Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophils
MC Chabot, JD Schmitt, BC Bullock… - Biochimica et Biophysica …, 1987 - Elsevier
Platelet activating factor (PAF) is rapidly metabolized via a deacetylation: reacylation
pathway which shows striking specificity for arachidonate at the sn-2 position of the 1-O-alkyl-
2-acyl-GPC thus formed. We have now examined the effects of a diet enriched in fish oils on
the metabolism of PAF and specificity for arachidonate in the reacylation reaction.[3 H] PAF
was incubated for various lengths of time with neutrophils from monkeys fed a control diet or
one enriched in fish oils. The [3 H] PAF added to the cell suspension was rapidly converted …
pathway which shows striking specificity for arachidonate at the sn-2 position of the 1-O-alkyl-
2-acyl-GPC thus formed. We have now examined the effects of a diet enriched in fish oils on
the metabolism of PAF and specificity for arachidonate in the reacylation reaction.[3 H] PAF
was incubated for various lengths of time with neutrophils from monkeys fed a control diet or
one enriched in fish oils. The [3 H] PAF added to the cell suspension was rapidly converted …
