[HTML][HTML] Bone morphogenetic protein-9: an autocrine/paracrine cytokine in the liver
AF Miller, SAK Harvey, RS Thies, MS Olson - Journal of Biological …, 2000 - ASBMB
Bone morphogenetic proteins (BMPs) occupy important roles during development serving to
direct cells through specific differentiation programs. While several BMPs are essential for
embryonic viability, their significance in mediating intercellular communication in the context
of adult organ systems remains largely unknown. In the adult rat we characterized the tissue-
and cell-specific transcription and translation of BMP-9. Utilizing a ribonuclease protection
assay, we determined that in the adult animal, BMP-9 expression occurs predominantly in …
direct cells through specific differentiation programs. While several BMPs are essential for
embryonic viability, their significance in mediating intercellular communication in the context
of adult organ systems remains largely unknown. In the adult rat we characterized the tissue-
and cell-specific transcription and translation of BMP-9. Utilizing a ribonuclease protection
assay, we determined that in the adult animal, BMP-9 expression occurs predominantly in …