Hepcidin is a circulating antimicrobial peptide which has been proposed to regulate the
uptake of dietary iron and its storage in reticuloendothelial macrophages. Transgenic mice
lacking hepcidin expression demonstrate abnormalities of iron homeostasis similar to Hfe
knockout mice and to patients with HFE-associated hereditary hemochromatosis (HH). To
identify any association between liver hepcidin expression and the iron homeostasis
abnormalities observed in HH, we compared liver hepcidin mRNA content in wild type and …