Investigation of the p.Ser278Arg polymorphism of the autoimmune regulator (AIRE) gene in alopecia areata
J Pforr, B Blaumeiser, T Becker… - Tissue …, 2006 - Wiley Online Library
J Pforr, B Blaumeiser, T Becker, Y Freudenberg‐Hua, S Hanneken, S Eigelshoven, I Cuyt…
Tissue Antigens, 2006•Wiley Online LibraryA recent study has suggested that the g. 961C> G (p. Ser278Arg) variant of the autoimmune
regulator (AIRE) gene contributes to susceptibility to alopecia areata (AA). We attempted to
replicate this finding using a case‐control sample of Belgian‐German origin (273 patients
and 283 controls). Despite adequate power, our study results do not support a significant
association of the risk allele in our AA patient sample. This remained the case when we
stratified our sample according to severity and family history of disease. Our study results do …
regulator (AIRE) gene contributes to susceptibility to alopecia areata (AA). We attempted to
replicate this finding using a case‐control sample of Belgian‐German origin (273 patients
and 283 controls). Despite adequate power, our study results do not support a significant
association of the risk allele in our AA patient sample. This remained the case when we
stratified our sample according to severity and family history of disease. Our study results do …
Abstract
A recent study has suggested that the g.961C>G (p.Ser278Arg) variant of the autoimmune regulator (AIRE) gene contributes to susceptibility to alopecia areata (AA). We attempted to replicate this finding using a case‐control sample of Belgian‐German origin (273 patients and 283 controls). Despite adequate power, our study results do not support a significant association of the risk allele in our AA patient sample. This remained the case when we stratified our sample according to severity and family history of disease. Our study results do not support the hypothesis that the g.961C>G (p.Ser278Arg) polymorphism of the AIRE gene is associated with an increased risk for AA.
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