Systemic lupus erythematosus: emerging concepts: part 2: dermatologic and joint disease, the antiphospholipid antibody syndrome, pregnancy and hormonal therapy …
DT Boumpas, BJ Fessler, HA Austin III… - Annals of internal …, 1995 - acpjournals.org
Purpose: To review 1) advances in the pathogenesis, diagnosis, and management of
dermatologic and joint disease and the antiphospholipid antibody syndrome in patients with
systemic lupus erythematosus; 2) controversies related to pregnancy and hormonal therapy
and to morbidity and mortality in these patients; and 3) current views on the pathogenesis of
systemic lupus erythematosus. Data Sources and Study Selection: Review of the English-
language medical literature with emphasis on articles published within the last 5 years. More …
dermatologic and joint disease and the antiphospholipid antibody syndrome in patients with
systemic lupus erythematosus; 2) controversies related to pregnancy and hormonal therapy
and to morbidity and mortality in these patients; and 3) current views on the pathogenesis of
systemic lupus erythematosus. Data Sources and Study Selection: Review of the English-
language medical literature with emphasis on articles published within the last 5 years. More …
Genetic susceptibility to systemic lupus erythematosus
TJ Vyse, BL Kotzin - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Considerable evidence suggests that the development of systemic lupus
erythematosus (SLE) has a strong genetic basis. Recent studies have emphasized that this
disease, like other autoimmune diseases, is a complex genetic trait with contributions from
major histocompatibility complex (MHC) genes and multiple non-MHC genes. Etiologic
genes in these disorders determine susceptibility, and no particular gene is necessary or
sufficient for disease expression. Studies of murine models of lupus have provided important …
erythematosus (SLE) has a strong genetic basis. Recent studies have emphasized that this
disease, like other autoimmune diseases, is a complex genetic trait with contributions from
major histocompatibility complex (MHC) genes and multiple non-MHC genes. Etiologic
genes in these disorders determine susceptibility, and no particular gene is necessary or
sufficient for disease expression. Studies of murine models of lupus have provided important …
Genetic basis of systemic lupus erythematosus
TJ Vyse, BL Kotzin - Current opinion in immunology, 1996 - Elsevier
Recent studies have emphasized that systemic lupus erythematosus is a complex genetic
trait with contributions from the MHC and multiple non-MHC genes. Genome-wide linkage
studies in murine models of lupus have mapped the positions of a number of non-MHC loci,
but the contributing genes have not yet been identified. Recent studies in human systemic
lupus erythematosus have found an association with a particular FCGR2A allele. Although
susceptibility genes in lupus are unlikely to involve mutations with severe functional …
trait with contributions from the MHC and multiple non-MHC genes. Genome-wide linkage
studies in murine models of lupus have mapped the positions of a number of non-MHC loci,
but the contributing genes have not yet been identified. Recent studies in human systemic
lupus erythematosus have found an association with a particular FCGR2A allele. Although
susceptibility genes in lupus are unlikely to involve mutations with severe functional …