Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery
ML Lamy, EK Daily, JF Brichant… - The Journal of the …, 2000 - pubs.asahq.org
Background Risks associated with transfusion of allogeneic blood have prompted
development of methods to avoid or reduce blood transfusions. New oxygen-carrying
compounds such as diaspirin cross-linked hemoglobin (DCLHb) could enable more patients
to avoid allogeneic blood transfusion. Methods The efficacy, safety, hemodynamic effects,
and plasma persistence of DCLHb were investigated in a randomized, active-control, single-
blind, multicenter study in post-cardiac bypass surgery patients. Of 1,956 screened patients …
development of methods to avoid or reduce blood transfusions. New oxygen-carrying
compounds such as diaspirin cross-linked hemoglobin (DCLHb) could enable more patients
to avoid allogeneic blood transfusion. Methods The efficacy, safety, hemodynamic effects,
and plasma persistence of DCLHb were investigated in a randomized, active-control, single-
blind, multicenter study in post-cardiac bypass surgery patients. Of 1,956 screened patients …