Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
H Wo Tsui, KA Siminovitch, L de Souza, FWL Tsui - Nature genetics, 1993 - nature.com
H Wo Tsui, KA Siminovitch, L de Souza, FWL Tsui
Nature genetics, 1993•nature.comMice with the recessive motheaten (me) or the allelic viable motheaten (me v) mutations
express a severe autoimmune and immunodeficiency syndrome. We have shown that the
basic defect in these mice involves lesions in the gene which encodes haematopoietic cell
phosphatase (HCP). These mice thus provide excellent models for investigating the roles of
phosphatases in haematopoiesis and the nature of the genetic and cellular events linking
impaired haematopoiesis to severe immunodeficiency and expression of systemic …
express a severe autoimmune and immunodeficiency syndrome. We have shown that the
basic defect in these mice involves lesions in the gene which encodes haematopoietic cell
phosphatase (HCP). These mice thus provide excellent models for investigating the roles of
phosphatases in haematopoiesis and the nature of the genetic and cellular events linking
impaired haematopoiesis to severe immunodeficiency and expression of systemic …
Abstract
Mice with the recessive motheaten (me) or the allelic viable motheaten (mev) mutations express a severe autoimmune and immunodeficiency syndrome. We have shown that the basic defect in these mice involves lesions in the gene which encodes haematopoietic cell phosphatase (HCP). These mice thus provide excellent models for investigating the roles of phosphatases in haematopoiesis and the nature of the genetic and cellular events linking impaired haematopoiesis to severe immunodeficiency and expression of systemic autoimmunity.
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