Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus
S Patterson, A Rae, N Hockey, J Gilmour… - Journal of …, 2001 - Am Soc Microbiol
S Patterson, A Rae, N Hockey, J Gilmour, F Gotch
Journal of virology, 2001•Am Soc MicrobiolPlasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to
express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-
type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both
DC types were more susceptible to infection with a macrophage than a lymphotropic strain
of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.
express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-
type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both
DC types were more susceptible to infection with a macrophage than a lymphotropic strain
of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.
Abstract
Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.
American Society for Microbiology