Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-α …
P Gervois, R Kleemann, A Pilon, F Percevault… - Journal of Biological …, 2004 - ASBMB
The peroxisome proliferator-activated receptor α (PPARα), which is highly expressed in liver,
plays key roles in lipid metabolism and inflammation. Interleukin-6 (IL-6) is the principal
inducer of acute phase response (APR) gene expression. In the present study, we
demonstrate that chronic treatment with the PPARα agonist fenofibrate fully prevents the IL-6-
induced APR gene expression in wild-type but not in PPARα-deficient mice. PPARα
prevents the IL-6-induced expression of the positive APR genes fibrinogen-α,-β,-γ …
plays key roles in lipid metabolism and inflammation. Interleukin-6 (IL-6) is the principal
inducer of acute phase response (APR) gene expression. In the present study, we
demonstrate that chronic treatment with the PPARα agonist fenofibrate fully prevents the IL-6-
induced APR gene expression in wild-type but not in PPARα-deficient mice. PPARα
prevents the IL-6-induced expression of the positive APR genes fibrinogen-α,-β,-γ …
