[HTML][HTML] Complex regulation of human neuronal nitric-oxide synthase exon 1c gene transcription: essential role of Sp and ZNF family members of transcription factors
D Saur, B Seidler, H Paehge, V Schusdziarra… - Journal of Biological …, 2002 - ASBMB
Neuronal nitric-oxide synthase (nNOS) is expressed in a variety of human tissues and
shows a complex transcriptional regulation with the presence of nine alternative first exons
(1a–1i) resulting in nNOS transcripts with differing 5′-untranslated regions. We previously
demonstrated that nNOS exon 1c, one of the predominant transcripts in the human
gastrointestinal tract, is driven by a separate promoter (Saur, D., Paehge, H., Schusdziarra,
V., and Allescher, HD (2000) Gastroenterology 118, 849–858). The present study focused …
shows a complex transcriptional regulation with the presence of nine alternative first exons
(1a–1i) resulting in nNOS transcripts with differing 5′-untranslated regions. We previously
demonstrated that nNOS exon 1c, one of the predominant transcripts in the human
gastrointestinal tract, is driven by a separate promoter (Saur, D., Paehge, H., Schusdziarra,
V., and Allescher, HD (2000) Gastroenterology 118, 849–858). The present study focused …