Nitric oxide synthases: roles, tolls, and controls

C Nathan, Q Xie - Cell, 1994 - cell.com
C Nathan, Q Xie
Cell, 1994cell.com
Rab proteins are generally required for transport vesicle docking. We have exploited yeast
secretion mutants to demonstrate that a rab protein is required for v-SNAREs and t-SNAREs
to assemble. The absence of the rab protein in the docking complex suggests that, in a
broad sense, rab proteins participate in a reaction catalyzing SNARE complex assembly. In
so doing, rab proteins could help impart an additional layer of specificity to vesicle docking.
This mechanism likely involves the Sec1 homolog Sly1, which we identified in isolated …
Rab proteins are generally required for transport vesicle docking. We have exploited yeast secretion mutants to demonstrate that a rab protein is required for v-SNAREs and t-SNAREs to assemble. The absence of the rab protein in the docking complex suggests that, in a broad sense, rab proteins participate in a reaction catalyzing SNARE complex assembly. In so doing, rab proteins could help impart an additional layer of specificity to vesicle docking. This mechanism likely involves the Sec1 homolog Sly1, which we identified in isolated docking complexes.
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