Arterial hypoxemia in awake dogs: role of the sympathetic nervous system in mediating the systemic hemodynamic and regional blood flow responses
JU Doherty, CS Liang - The Journal of laboratory and clinical …, 1984 - translationalres.com
The role of the sympathetic nervous system in the systemic hemodynamic and regional
blood flow responses to hypoxia was studied in awake dogs by preexposing the animals to
phentolamine alone (α block) or to phentolamine plus propranolol (α+ β block). Hypoxia was
produced by switching from room air to either an 8% or 5% oxygen-nitrogen mixture. During
8% oxygen breathing, cardiac output, heart rate, left ventricular dPdt, dP/dt/P, myocardial
oxygen consumption, and myocardial blood flow increased, and both total peripheral and …
blood flow responses to hypoxia was studied in awake dogs by preexposing the animals to
phentolamine alone (α block) or to phentolamine plus propranolol (α+ β block). Hypoxia was
produced by switching from room air to either an 8% or 5% oxygen-nitrogen mixture. During
8% oxygen breathing, cardiac output, heart rate, left ventricular dPdt, dP/dt/P, myocardial
oxygen consumption, and myocardial blood flow increased, and both total peripheral and …