Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test
RF Genn, S Tucci, EM Marco, MP Viveros… - Pharmacology …, 2004 - Elsevier
In spite of the addictive properties of cannabinoids, under certain circumstances, they can
evoke strong anxiogenic and aversive responses in humans and in animal tests of anxiety.
Effects of different doses of CP 55,940 (10, 20, and 40 μg/kg) were tested in the low-light,
familiar (LF) apparatus test condition of the social interaction test. The 40-μg/kg dose of CP
55,940 significantly decreased the time spent in social interaction, indicating an anxiogenic
effect. This dose also had an independent effect of reducing locomotor activity. In rats tested …
evoke strong anxiogenic and aversive responses in humans and in animal tests of anxiety.
Effects of different doses of CP 55,940 (10, 20, and 40 μg/kg) were tested in the low-light,
familiar (LF) apparatus test condition of the social interaction test. The 40-μg/kg dose of CP
55,940 significantly decreased the time spent in social interaction, indicating an anxiogenic
effect. This dose also had an independent effect of reducing locomotor activity. In rats tested …