[HTML][HTML] FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and-independent mechanisms
Emerging evidence documents a key function for the forkhead transcription factor FoxO1 in
cellular metabolism. Here, we investigate the role of FoxO1 in the regulation of fatty acid (FA)
metabolism in muscle cells. C2C12 cells expressing an inducible construct with either wild
type FoxO1 or a mutant form (FoxO1/TSS) refractory to the protein kinase B inhibitory effects
were generated. FoxO1 activation after myotube formation altered the expression of several
genes of FA metabolism. Acyl-CoA oxidase and peroxisome proliferator-activated receptor δ …
cellular metabolism. Here, we investigate the role of FoxO1 in the regulation of fatty acid (FA)
metabolism in muscle cells. C2C12 cells expressing an inducible construct with either wild
type FoxO1 or a mutant form (FoxO1/TSS) refractory to the protein kinase B inhibitory effects
were generated. FoxO1 activation after myotube formation altered the expression of several
genes of FA metabolism. Acyl-CoA oxidase and peroxisome proliferator-activated receptor δ …