▪ Abstract The cAMP responsive element binding protein (CREB) is a nuclear protein that
modulates the transcription of genes with cAMP responsive elements in their promoters.
Increases in the concentration of either calcium or cAMP can trigger the phosphorylation and
activation of CREB. This transcription factor is a component of intracellular signaling events
that regulate a wide range of biological functions, from spermatogenesis to circadian
rhythms and memory. Here we review the key features of CREB-dependent transcription, as …