β‐Chemokines MCP‐1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus–associated dementia
W Kelder, JC McArthur, T Nance‐Sproson… - Annals of …, 1998 - Wiley Online Library
W Kelder, JC McArthur, T Nance‐Sproson, D McClernon, DE Griffin
Annals of neurology, 1998•Wiley Online LibraryHuman immunodeficiency virus–associated dementia (HAD) is associated with increased
numbers of activated central nervous system (CNS) macrophages. Chemokines, which
regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of
human immunodeficiency virus (HIV)‐negative and HIV‐positive individuals with and
without neurological disese. Monocyte chemotactic protein (MCP)‐1 and RANTES (but not
MCP‐3), macrophage inflammatory protein (MIP)‐1α, MIP‐1β, or interleukin‐8 (IL‐8) was …
numbers of activated central nervous system (CNS) macrophages. Chemokines, which
regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of
human immunodeficiency virus (HIV)‐negative and HIV‐positive individuals with and
without neurological disese. Monocyte chemotactic protein (MCP)‐1 and RANTES (but not
MCP‐3), macrophage inflammatory protein (MIP)‐1α, MIP‐1β, or interleukin‐8 (IL‐8) was …
Abstract
Human immunodeficiency virus–associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)‐negative and HIV‐positive individuals with and without neurological disese. Monocyte chemotactic protein (MCP)‐1 and RANTES (but not MCP‐3), macrophage inflammatory protein (MIP)‐1α, MIP‐1β, or interleukin‐8 (IL‐8) was higher in HAD. MCP‐1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.
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