Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells
A Sachinidis, P Weisser, Y Ko, K Schulte… - FEBS letters, 1992 - Elsevier
A Sachinidis, P Weisser, Y Ko, K Schulte, KM zu Brickwedde, L Neyses, H Vetter
FEBS letters, 1992•ElsevierThe effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on
the Egr-1 protein and on the phosphoinositide PI turnover signalling system was
investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor
antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1
protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-
induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the …
the Egr-1 protein and on the phosphoinositide PI turnover signalling system was
investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor
antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1
protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-
induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the …
Abstract
The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.
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