[HTML][HTML] A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (vascular endothelial growth factor receptor 1) …

K Wakiya, A Begue, D Stehelin, M Shibuya - Journal of Biological Chemistry, 1996 - ASBMB
The flt-1 gene encodes a transmembrane tyrosine kinase, Flt-1, a receptor for vascular
endothelial growth factor. The expression of flt-1 gene is restricted to endothelial cells in
vivo. To understand the molecular mechanism underlying endothelial-specific expression of
this gene, we studied the functional significance of transcriptional motifs in the 200-base pair
region of the human flt-1 gene promoter, which has been identified to confer cell type
specificity. By point mutation analysis using chloramphenicol acetyltransferase plasmids in …