[HTML][HTML] Alpha C protein of group B Streptococcus binds host cell surface glycosaminoglycan and enters cells by an actin-dependent mechanism
MJ Baron, GR Bolduc, MB Goldberg, TC Aupérin… - Journal of biological …, 2004 - ASBMB
Group B Streptococcus (GBS) colonizes mucosal surfaces of the human gastrointestinal and
gynecological tracts and causes disease in a wide range of patients. Invasive illness occurs
after organisms traverse an epithelial boundary and enter deeper tissues. Previously we
have reported that the alpha C protein (ACP) on the surface of GBS mediates GBS entry into
ME180 cervical epithelial cells and GBS translocation across layers of these cells. We now
demonstrate that ACP interacts with host cell glycosaminoglycan (GAG); the interaction of …
gynecological tracts and causes disease in a wide range of patients. Invasive illness occurs
after organisms traverse an epithelial boundary and enter deeper tissues. Previously we
have reported that the alpha C protein (ACP) on the surface of GBS mediates GBS entry into
ME180 cervical epithelial cells and GBS translocation across layers of these cells. We now
demonstrate that ACP interacts with host cell glycosaminoglycan (GAG); the interaction of …