Selective uptake of low-density lipoprotein-associated cholesteryl esters by human fibroblasts, human HepG2 hepatoma cells and J774 macrophages in culture
F Rinninger, M Brundert, S Jäckle, T Kaiser… - Biochimica et Biophysica …, 1995 - Elsevier
High-density lipoprotein-(HDL) associated cholesteryl esters (CE) are taken up by hepatic
and extrahepatic cells at a higher rate than HDL apolipoproteins. This selective uptake of
HDL CE is independent from HDL particle uptake. For low-density lipoprotein (LDL),
receptor-mediated endocytosis by cells is well established. In this study, the question was
addressed if LDL-associated CE are also taken up by cells independently from LDL
particles, ie, selectively. Human LDL (d= 1.02–1.05 g/ml) was doubly radiolabeled with …
and extrahepatic cells at a higher rate than HDL apolipoproteins. This selective uptake of
HDL CE is independent from HDL particle uptake. For low-density lipoprotein (LDL),
receptor-mediated endocytosis by cells is well established. In this study, the question was
addressed if LDL-associated CE are also taken up by cells independently from LDL
particles, ie, selectively. Human LDL (d= 1.02–1.05 g/ml) was doubly radiolabeled with …