Heparan sulfate proteoglycans mediate internalization and degradation of beta-VLDL and promote cholesterol accumulation by pigeon macrophages
T Seo, RW St Clair - Journal of lipid research, 1997 - ASBMB
Pigeon and rabbit beta-migrating very low density lipoprotein (beta-VLDL) are similar in size
and composition, yet rabbit beta-VLDL consistently stimulates greater cholesteryl ester
accumulation in pigeon peritoneal macrophages than does pigeon beta-VLDL. The purpose
of this study was to determine the mechanism of this difference. Pigeon beta-VLDL bound to
both a high and low affinity site while rabbit beta-VLDL bound primarily to a low affinity site.
The high affinity site had the characteristics of the LDL receptor. Most rabbit beta-VLDL and …
and composition, yet rabbit beta-VLDL consistently stimulates greater cholesteryl ester
accumulation in pigeon peritoneal macrophages than does pigeon beta-VLDL. The purpose
of this study was to determine the mechanism of this difference. Pigeon beta-VLDL bound to
both a high and low affinity site while rabbit beta-VLDL bound primarily to a low affinity site.
The high affinity site had the characteristics of the LDL receptor. Most rabbit beta-VLDL and …