[HTML][HTML] A CD36-initiated signaling cascade mediates inflammatory effects of β-amyloid
KJ Moore, J El Khoury, LA Medeiros, K Terada… - Journal of Biological …, 2002 - ASBMB
β-Amyloid accumulation is associated with pathologic changes in the brain in Alzheimer's
disease and has recently been identified in plaques of another chronic inflammatory
disorder, atherosclerosis. The class B scavenger receptor, CD36, mediates binding of
fibrillar β-amyloid to cells of the monocyte/macrophage lineage, including brain
macrophages (microglia). In this study, we demonstrate that in microglia and other tissue
macrophages, β-amyloid initiates a CD36-dependent signaling cascade involving the Src …
disease and has recently been identified in plaques of another chronic inflammatory
disorder, atherosclerosis. The class B scavenger receptor, CD36, mediates binding of
fibrillar β-amyloid to cells of the monocyte/macrophage lineage, including brain
macrophages (microglia). In this study, we demonstrate that in microglia and other tissue
macrophages, β-amyloid initiates a CD36-dependent signaling cascade involving the Src …