Anemia of inflammation: the cytokine-hepcidin link
NC Andrews - The Journal of clinical investigation, 2004 - jci.org
The Journal of clinical investigation, 2004•jci.org
The anemia of inflammation, commonly observed in patients with chronic infections,
malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until
recently, we understood little about its pathogenesis. It now appears that the inflammatory
cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be
responsible for most or all of the features of this disorder.
malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until
recently, we understood little about its pathogenesis. It now appears that the inflammatory
cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be
responsible for most or all of the features of this disorder.
The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
The Journal of Clinical Investigation