T-cell antigen receptor peptides inhibit signal transduction within the membrane bilayer
XM Wang, JT Djordjevic, N Kurosaka, S Schibeci… - Clinical …, 2002 - Elsevier
Previous studies have shown that a synthetic peptide (core peptide, CP) corresponding to a
9-amino-acid region in the transmembrane domain of the α subunit of the T-cell antigen
receptor (TCR) can suppress T-cell function in vitro and in vivo. The aim of these
experiments was to determine the cellular site and molecular mechanism of CP inhibition in
T cells. The cytochrome c-sensitive TCR-expressing hybridoma (2B4) was stimulated with
pigeon cytochrome c antigen, anti-CD3 crosslinking, or PMA and ionomycin, in the presence …
9-amino-acid region in the transmembrane domain of the α subunit of the T-cell antigen
receptor (TCR) can suppress T-cell function in vitro and in vivo. The aim of these
experiments was to determine the cellular site and molecular mechanism of CP inhibition in
T cells. The cytochrome c-sensitive TCR-expressing hybridoma (2B4) was stimulated with
pigeon cytochrome c antigen, anti-CD3 crosslinking, or PMA and ionomycin, in the presence …