The Evaluation of Subcutaneous Proleukin®(interleukin-2) in a Randomized International Trial: rationale, design, and methods of ESPRIT
S Emery, DI Abrams, DA Cooper, JH Darbyshire… - Controlled clinical …, 2002 - Elsevier
The Evaluation of Subcutaneous Proleukin® in a Randomized International Trial (ESPRIT)
is a large ongoing randomized trial of subcutaneous interleukin-2 (IL-2) plus antiretroviral
therapy versus antiretroviral therapy alone in patients with HIV (human immunodeficiency
virus) disease and CD4 cell counts of at least 300 cells/mm3. The primary objective is to
determine whether the addition of IL-2 to combination antiretroviral therapy improves
morbidity and mortality. The aim is to recruit 4000 participants and follow them for an …
is a large ongoing randomized trial of subcutaneous interleukin-2 (IL-2) plus antiretroviral
therapy versus antiretroviral therapy alone in patients with HIV (human immunodeficiency
virus) disease and CD4 cell counts of at least 300 cells/mm3. The primary objective is to
determine whether the addition of IL-2 to combination antiretroviral therapy improves
morbidity and mortality. The aim is to recruit 4000 participants and follow them for an …