[HTML][HTML] Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
Y Fujio, K Walsh - Journal of Biological Chemistry, 1999 - ASBMB
Regulation of endothelial cell apoptosis is a critical modulator of normal and pathological
angiogenesis. In this study, we examined the role of the protein kinase Akt/PKB in
endothelial cell survival in response to growth factor and matrix attachment signals. Vascular
endothelial growth factor (VEGF)-induced cytoprotection of endothelial cell monolayers
correlated with the wortmannin-sensitive induction of Akt activity. Transfection of an
adenovirus expressing a dominant-negative Akt mutant decreased endothelial cell viability …
angiogenesis. In this study, we examined the role of the protein kinase Akt/PKB in
endothelial cell survival in response to growth factor and matrix attachment signals. Vascular
endothelial growth factor (VEGF)-induced cytoprotection of endothelial cell monolayers
correlated with the wortmannin-sensitive induction of Akt activity. Transfection of an
adenovirus expressing a dominant-negative Akt mutant decreased endothelial cell viability …