[HTML][HTML] Gβγ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

SVN Prasad, G Esposito, L Mao, WJ Koch… - Journal of Biological …, 2000 - ASBMB
Activation of phosphoinositide 3-kinases is coupled to both phosphotyrosine/growth factor
and G protein-coupled receptors. We explored the role of phosphoinositide 3-kinase
activation in myocardium during in vivo pressure overload hypertrophy in mice. Cytosolic
extracts from wild type hypertrophied hearts showed a selective increase in the
phosphoinositide 3-kinase γ isoform. To address the role of G protein-coupled receptor-
mediated activation of phosphoinositide 3-kinase, we used transgenic mice with cardiac …