[HTML][HTML] Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

H Cho, JL Thorvaldsen, Q Chu, F Feng… - Journal of Biological …, 2001 - ASBMB
The serine-threonine kinase Akt, also known as protein kinase B (PKB), is an important
effector for phosphatidylinositol 3-kinase signaling initiated by numerous growth factors and
hormones. Akt2/PKBβ, one of three known mammalian isoforms of Akt/PKB, has been
demonstrated recently to be required for at least some of the metabolic actions of insulin
(Cho, H., Mu, J., Kim, JK, Thorvaldsen, JL, Chu, Q., Crenshaw, EB, Kaestner, KH, Bartolomei,
MS, Shulman, GI, and Birnbaum, MJ (2001) Science292, 1728–1731). Here we show that …