Malignant Hyperthermia and Central Core Disease: Disorders of Ca2 Release Channels1
J Loke, DH MacLennan - The American journal of medicine, 1998 - amjmed.com
Muscle contraction and relaxation result from the interplay between two elaborate cellular
structures and the small molecule, Ca2+, which cycles between them. The contractile
elements are formed as short, repeating segments referred to as sarcomeres (1, 2). Within
sarcomeres, longitudinally aligned, centrally located, thick filaments contain myosin, the
adenosine triphosphate (ATP)-activated motor for the generation of contractile force (Figure
1). Thick filaments interdigitate between similarly aligned thin filaments that are anchored at …
structures and the small molecule, Ca2+, which cycles between them. The contractile
elements are formed as short, repeating segments referred to as sarcomeres (1, 2). Within
sarcomeres, longitudinally aligned, centrally located, thick filaments contain myosin, the
adenosine triphosphate (ATP)-activated motor for the generation of contractile force (Figure
1). Thick filaments interdigitate between similarly aligned thin filaments that are anchored at …