Fig. 1 Pedigrees and symptoms of the PCCD families. a, Pedigree of the French family. Patients with an unknown status (stippled) were not included in the linkage study. Individuals carrying the mutation are indicated (+), as are patients with a pacemaker (PM). b, Representative ECGs from the French family. Patient II-1 had an unspecified conduction defect (QRS duration 120 ms) at age 60, but at age 72 had left anterior hemi-block with wide QRS complexes and a long PR interval (240 ms). ECGs from patients II-7, III-17 and IV-18 show complete LBBB, complete RBBB and left posterior hemi-block, respectively. c, Pedigree of the Dutch family. a c b patient II-1 patient II-7 patient III-17 patient IV-18