[HTML][HTML] Sodium channel β1 subunit-mediated modulation of Nav1. 2 currents and cell surface density is dependent on interactions with contactin and ankyrin
DP McEwen, LS Meadows, C Chen… - Journal of Biological …, 2004 - ASBMB
Voltage-gated sodium channels are composed of a pore-forming α subunit and at least one
auxiliary β subunit. Both β1 and β2 are cell adhesion molecules that interact homophilically,
resulting in ankyrin recruitment. In contrast, β1, but not β2, interacts heterophilically with
contactin, resulting in increased levels of cell surface sodium channels. We took advantage
of these results to investigate the molecular basis of β1-mediated enhancement of sodium
channel cell surface density, including elucidating structure-function relationships for β1 …
auxiliary β subunit. Both β1 and β2 are cell adhesion molecules that interact homophilically,
resulting in ankyrin recruitment. In contrast, β1, but not β2, interacts heterophilically with
contactin, resulting in increased levels of cell surface sodium channels. We took advantage
of these results to investigate the molecular basis of β1-mediated enhancement of sodium
channel cell surface density, including elucidating structure-function relationships for β1 …