[HTML][HTML] Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin
P Rodien, C Brémont, MLR Sanson… - … England Journal of …, 1998 - Mass Medical Soc
P Rodien, C Brémont, MLR Sanson, J Parma, J Van Sande, S Costagliola, JP Luton…
New England Journal of Medicine, 1998•Mass Medical SocSome degree of stimulation of the thyroid gland by human chorionic gonadotropin is
common during early pregnancy. 1–3 When serum chorionic gonadotropin concentrations
are abnormally high—for example, in women with molar pregnancies—overt
hyperthyroidism may ensue. The pathophysiologic mechanism is believed to be
promiscuous stimulation of the thyrotropin receptor by the excess chorionic gonadotropin. 4,
5 The explanation for this stimulation is the close structural relations between chorionic …
common during early pregnancy. 1–3 When serum chorionic gonadotropin concentrations
are abnormally high—for example, in women with molar pregnancies—overt
hyperthyroidism may ensue. The pathophysiologic mechanism is believed to be
promiscuous stimulation of the thyrotropin receptor by the excess chorionic gonadotropin. 4,
5 The explanation for this stimulation is the close structural relations between chorionic …
Some degree of stimulation of the thyroid gland by human chorionic gonadotropin is common during early pregnancy.1–3 When serum chorionic gonadotropin concentrations are abnormally high — for example, in women with molar pregnancies — overt hyperthyroidism may ensue. The pathophysiologic mechanism is believed to be promiscuous stimulation of the thyrotropin receptor by the excess chorionic gonadotropin.4,5 The explanation for this stimulation is the close structural relations between chorionic gonadotropin and thyrotropin and between their receptors.6
Hyperemesis gravidarum is characterized by excessive vomiting in early pregnancy, leading to the loss of 5 percent or more of body weight.4 It . . .
The New England Journal Of Medicine