Somatic mutations in thyroid nodular disease
K Krohn, R Paschke - Molecular genetics and metabolism, 2002 - Elsevier
Thyroid nodules can be found in up to 50% of inhabitants of iodine-deficient areas and are
classified as hot or cold thyroid nodules according to their scintigraphic characteristics.
Studies of hot thyroid nodules with comparable mutation detection methods and screening
at least exon 10 of the TSH receptor reported frequencies for somatic TSH-receptor
mutations ranging from 20 to 82% in patients with similar iodine supply. We have recently
screened 75 hot thyroid nodules for somatic TSH-receptor mutations with the more sensitive …
classified as hot or cold thyroid nodules according to their scintigraphic characteristics.
Studies of hot thyroid nodules with comparable mutation detection methods and screening
at least exon 10 of the TSH receptor reported frequencies for somatic TSH-receptor
mutations ranging from 20 to 82% in patients with similar iodine supply. We have recently
screened 75 hot thyroid nodules for somatic TSH-receptor mutations with the more sensitive …