Induction of thyroid proliferative changes in rats treated with antithyroid compound

AF Rodriguez, HG Davidson… - Anatomia, Histologia …, 1991 - Wiley Online Library
AF Rodriguez, HG Davidson, MS Villadiego, AM Fernandez, IM Lacave, JF Sanz
Anatomia, Histologia, Embryologia, 1991Wiley Online Library
This study was designed to investigate the histologic changes in goitrogen‐induced thyroid
growth of the rat. The animals were orally treated by 1% potassium perchlorate except the
controls and were sacrificed in intervals ranging from 1 to 12 months. The thyroid weight
increased progressively along the treatment and after 2 months showed a diffuse
homogeneous hypertrophy and hyperplasia of follicular cells, decreased amount of colloid
and increased vascularity. After sixth month of treatment true nodules appeared with …
Summary
This study was designed to investigate the histologic changes in goitrogen‐induced thyroid growth of the rat. The animals were orally treated by 1 % potassium perchlorate except the controls and were sacrificed in intervals ranging from 1 to 12 months.
The thyroid weight increased progressively along the treatment and after 2 months showed a diffuse homogeneous hypertrophy and hyperplasia of follicular cells, decreased amount of colloid and increased vascularity. After sixth month of treatment true nodules appeared with complex morphology.
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