[HTML][HTML] Shedding of Human Thyrotropin Receptor Ectodomain: INVOLVEMENT OF A MATRIX METALLOPROTEASE (∗)

J Couet, S Sar, A Jolivet, MTV Hai, E Milgrom… - Journal of Biological …, 1996 - ASBMB
The thyrotropin (TSH) receptor in human thyroid glands has been shown to be cleaved into
an extracellular α subunit and a transmembrane β subunit held together by disulfide bridges.
An excess of the latter component relative to the former suggested the shedding of the
ectodomain. Indeed we observed such a shedding in cultures of human thyrocytes and
permanently transfected L or Chinese hamster ovary cells. The shedding was increased by
inhibitors of endocytosis, recycling, and lysosomal degradation, suggesting that it was …