Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin …
CA Stuart, G Wen, ME Williamson… - Metabolism …, 2001 - metabolismjournal.com
Multiple isoforms of glucose transporters are found in muscle, the tissue that normally
accounts for 85% of insulin-stimulated glucose uptake. Glucose uptake into muscle cells in
the fasting state is mediated primarily by GLUT1 and GLUT3 glucose transporters, whereas
postprandial (insulin-stimulated) and exercise-related increments in muscle glucose uptake
are mediated primarily by GLUT4. To determine if glucose transporters are abnormally
expressed in muscle from insulin-resistant subjects, muscle samples were obtained from 10 …
accounts for 85% of insulin-stimulated glucose uptake. Glucose uptake into muscle cells in
the fasting state is mediated primarily by GLUT1 and GLUT3 glucose transporters, whereas
postprandial (insulin-stimulated) and exercise-related increments in muscle glucose uptake
are mediated primarily by GLUT4. To determine if glucose transporters are abnormally
expressed in muscle from insulin-resistant subjects, muscle samples were obtained from 10 …