Therapeutic antitumor response after immunization with an admixture of recombinant vaccinia viruses expressing a modified MUC1 gene and the murine T-cell …
J Akagi, JW Hodge, JP McLaughlin, L Gritz… - Journal of …, 1997 - journals.lww.com
Tumor-associated antigens have considerable promise not only as diagnostic or prognostic
markers but also as targets for active or passive immunotherapy, DF3/MUC1 is a tumor-
associated antigen that is overexpressed with an abnormal glycosylation pattern in breast,
ovarian, lung, and pancreatic cancers. The major extracellular portion of MUC1 is composed
of tandem repeat units of 20 amino acids. Recombinant vaccinia viruses encoding mucin
molecules have been constructed by several groups. However, these recombinants have …
markers but also as targets for active or passive immunotherapy, DF3/MUC1 is a tumor-
associated antigen that is overexpressed with an abnormal glycosylation pattern in breast,
ovarian, lung, and pancreatic cancers. The major extracellular portion of MUC1 is composed
of tandem repeat units of 20 amino acids. Recombinant vaccinia viruses encoding mucin
molecules have been constructed by several groups. However, these recombinants have …