Relevance of tumor microenvironment for progression, therapy and drug development

T Henning, M Kraus, M Brischwein, AM Otto… - Anti-Cancer …, 2004 - journals.lww.com
Tumor interstitium exhibits a microenvironment that differs from corresponding normal
tissues. Tumor phenotype shows, for example, an elevated intracellular pH (pH i), a lowered
extracellular pH (pH e), a low oxygen concentration and low glucose levels. These
differences are caused by cell biological (so called intrinsic) factors, eg a higher acidification
rate, as well as by more systemic (extrinsic) factors, eg poor tumor vascularization. They
represent important factors for invasiveness, immune suppression and proliferation, and …